(Download) "Standards for Plasma and Serum Proteomics in Early Cancer Detection: A Needs Assessment Report from the National Institute of Standards and Technology-National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19, 2005 (Overview)" by Clinical Chemistry # Book PDF Kindle ePub Free
eBook details
- Title: Standards for Plasma and Serum Proteomics in Early Cancer Detection: A Needs Assessment Report from the National Institute of Standards and Technology-National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19, 2005 (Overview)
- Author : Clinical Chemistry
- Release Date : January 01, 2006
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 259 KB
Description
Collection and analysis of comprehensive proteome data will be considerably more challenging than the human genome project. Whereas the human genome encodes ~22 000 genes (1), the human proteome is far more complex (2, 3). Multiple protein isoforms arise from the same gene by differential splicing, multitudinous post-translational modifications (4, 5), wider chemical diversity among proteins than nucleic acids, and ex vivo degradation in specimens. All present substantial technical and data analysis challenges unique to proteomics. Without universal preanalytical processing and data standards for proteomics, comprehensive analysis is problematic (6). For early cancer detection, reports of novel protein biomarkers in plasma and serum have been difficult to reproduce (7). Consequently, proponents of plasma and serum proteomic biomarker discovery have argued for large-scale, international collaboration to optimize efficiency of global efforts (8-11). To be effective, this endeavor requires standardization, as well as common reference materials.
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