[DOWNLOAD] "Stability of Neuroactive Amino Acids in Cerebrospinal Fluid Under Various Conditions of Processing and Storage (Technical Briefs)" by Clinical Chemistry # eBook PDF Kindle ePub Free

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eBook details

• Title: Stability of Neuroactive Amino Acids in Cerebrospinal Fluid Under Various Conditions of Processing and Storage (Technical Briefs)
• Author : Clinical Chemistry
• Release Date : January 01, 1998
• Genre: Chemistry,Books,Science & Nature,
• Pages : * pages
• Size : 189 KB

Description

Free amino acids (AAs) are widely distributed within the central nervous system and play an important role as transmitters of synaptic excitation and/or modulators of synaptic function (1). Because the content of free AAs in cerebrospinal fluid (CSF) has been demonstrated to correlate with brain AA content (2), a reliable measurement of CSF AA concentrations is a potentially useful tool for investigating central nervous system function. Changes in concentrations of AAs with known excitatory function, e.g., aspartate (ASP) and glutamate (GLU), or putative inhibitory function, e.g., glycine (GLY) and taurine (TAU), play an important role in the physiopathology of several neuropsychiatric disorders (3). Varying AA concentrations have been found in the CSF in controls and in neurological disorders. Increased, decreased, and unchanged concentrations of GLU have been observed in the CSF of epileptic patients (4-6). Initial studies provided evidence for increased concentrations of GLU and ASP in the CSF of patients with amyotrophic lateral sclerosis (7-8); however, subsequent studies reported CSF concentrations of ASP and GLU that were more than an order of magnitude lower (9). These discrepancies have been explained as the effects of different analytical methods or as the result of a lack of systematic evaluation of basic variables (e.g., age, sex, and severity of disease) (10); however, inappropriate CSF sample processing and storage could also explain these conflicting results.

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